Antidiabetic and antihyperlipidemic activity of leaves of Alstonia scholaris Linn. R.Br.

作者:Arulmozhi Sinnathambi*; Mazumder Papiya Mitra; Lohidasan Sathiyanarayanan; Thakurdesai Prasad
来源:European Journal of Integrative Medicine, 2010, 2(1): 23-32.
DOI:10.1016/j.eujim.2009.12.001

摘要

Aim of the study: Alstonia scholaris Linn. (R.Br.,) has been used in traditional and folklore medicine for the treatment of diabetes. The aim of the present study was to evaluate the effect of ethanolic extract of the leaves of A. scholaris (known as EEAS) in streptozotocin-induced diabetic rats.
Materials and methods: The streptozotocin-induced diabetic rats were orally treated with vehicle (2% w/v Tween 80), glibenclamide (0.25 mg/kg) and EEAS (100, 200 and 400 mg/kg) to the respective treatment groups. The blood glucose level, body weight, glycosylated hemoglobin, muscle and liver glycogen, lipid profile, lipid peroxidation, antioxidant status were measured and histopathology of pancreas was performed after 6 weeks of treatment and compared to the control.
Results: EEAS and glibenclamide were found to significantly (p < 0.001) reduce the blood glucose level, glycosylated hemoglobin and lipid peroxidation, whereas they increased body weight, liver and muscle glycogen and antioxidant status. The antidiabetic effect was sustained from 1 week onwards till the end of the study. The histopathology of pancreas revealed that the pancreatic beta-cell damage with streptozotocin did not reverse in any of the treatment groups.
Conclusion: It has been concluded that EEAS, in addition to the antidiabetic activity, also possess antihyperlipidemic and antioxidant activities in the streptozotocin-induced diabetic model.

  • 出版日期2010-4