An automated method for regular productions of copper-64 for PET radiopharmaceuticals

作者：Burke Paul; Golovko Oksana; Clark John C; Aigbirhio Franklin I^*

来源：Inorganica Chimica Acta, 2010, 363(6): 1316-1319.

DOI：10.1016/j.ica.2010.01.038

• Copper-64
• PET
• Radiopharmaceuticals
• Bis(thiosemicarbazones)

To facilitate the development of PET radiopharmaceuticals labelled with the positron-emitting radioisotope copper-64 (t(1/2) = 12.7 h) we have developed a fully automated method for its regular productions. Using the (64)Ni(p,n) (64)Cu nuclear reaction applied on a 16.5 MeV PETtrace cyclotron the radioisotope is generated in good yields (up to 2 GBq at end-of-synthesis) within 4 h irradiations on nickel-64 (99.6% enrichment) plated onto a gold disk. Based on ion exchange chromatography an automated method has been devised for efficient extraction of the copper-64 in good radionuclide and chemical purity, with ICP-OES analysis determining the concentration of the copper to be 0.14-1.5 ppm. The specific radioactivities of the copper-64 at end-of-synthesis were calculated to be 9.62-77 GB/mu mol. The copper-64 radioisotope obtained from this method was then applied to the radiosynthesis of the hypoxia markers, (64)Cu-ATSM and (64)Cu-ATSE, which were obtained in good radiochemical yields of >95%.

• 出版日期2010-4-5