Alginate-Hydroxyapatite Bone Scaffolds with Isotropic or Anisotropic Pore Structure: Material Properties and Biological Behavior

作者：Porrelli Davide; Travan Andrea; Turco Gianluca; Marsich Eleonora; Borgogna Massimiliano; Paoletti Sergio; Donati Ivan^*

来源：Macromolecular Materials and Engineering, 2015, 300(10): 989-1000.

DOI：10.1002/mame.201500055

• biological applications of polymers
• fillers
• ISISA
• oriented pores
• shape recovery

Alginate/hydroxyapatite composites, with isotropic or anisotropic porosity, were developed using two different freezing methods. Morphological analysis highlighted the differences in their three-dimensional network. Swelling and in vitro degradation studies revealed that both structures are highly hydrophilic and stable. Static compression tests showed that isotropic scaffolds possess higher modulus and toughness than anisotropic ones. Cyclic compression tests revealed that wet scaffolds are able to withstand high deformations with a peculiar shape-recovery behaviour. In vitro biological tests showed that osteoblast-like cells proliferate on both types of structures in a comparable manner.

• 出版日期2015-10