Acute Disseminating Encephalomyelitis Following Legionnaires Disease

作者：de Lau Lonneke M L^*; Siepman Dorine A M; Remmers Michel J M; Terwindt Gisela M; Hintzen Rogier Q

来源：Archives of Neurology, 2010, 67(5): 623-626.

DOI：10.1001/archneurol.2010.75

Objective: To describe 2 patients presenting with severe neurological deficits and extensive lesions on brain magnetic resonance imaging after having experienced Legionella pneumonia.
Design: Case reports.
Setting: University hospital.
Patients: Two patients who developed severe neurological symptoms, including encephalopathic signs, following Legionella infection, with widespread lesions on magnetic resonance imaging compatible with demyelination.
Results: After extensive ancillary investigations, a diagnosis of acute disseminating encephalomyelitis was considered most likely. Steroid therapy was initiated in 1 of the patients, followed by plasmapheresis. In both patients, clinical and radiological signs gradually recovered, with only slight residual deficits.
Conclusion: In patients presenting with neurological symptoms after an episode of pneumonia, Legionella infection and a subsequent immune-mediated process such as acute disseminating encephalomyelitis should be considered.

• 出版日期2010-5