科研之友
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摘要
Synthesis of novel alpha-aminophosphonic acid esters was achieved through a one-pot two-step reaction process (Pudovik reaction). In the first step tryptophan methyl ester is reacted with substituted aromatic aldehydes in absolute ethanol to form Schiff bases. In the second step, these are treated with dialkyl/diaryl phosphites in situ using sodium ethoxide as a catalyst at refluxing temperature. The structures of these compounds were established by elemental analyses IRS, (1)H, (13)C, (31)P NMR and mass spectral data. All the title compounds exhibited moderate antimicrobial activity.
- 出版日期2009
