Activity of Gossypol against Schistosoma japonicum

作者：Yang, FeiFei; Song, LiJun; Yin, XuRen; Shen, Shuang; Yu, ChuanXin^*; Tang, LuHong^*

来源：Latin American Journal of Pharmacy, 2016, 35(7): 1660-1663.

• antischistosomal activity
• in vitro study
• gossypol
• natural product
• Schistosoma japonicum

The chemotherapy of schistosomiasis relies on the use of praziquantel (PZQ). However concerns over drug resistance have encouraged the search for new drug leads. Gossypol, a valuable natural product, showed multiple biological properties, including antimalarial, antiparasitic and anticancer activities. The aim of this study was to investigate the in vitro antiparasitic effect of gossypol on Schistosoma japonicum. The results showed that gossypol killed 100% of juvenile S. japonicum at the concentration of 10 mu M in vitro in 48 h and killed 100% of adult S. japonicum at the concentration of 25 mu M in vitro in 48 h. These results indicated that gossypol could serve as a promising lead compound to develop new antischistosomal agents.

• 出版日期2016
• 单位江苏省血吸虫病防治研究所; 江南大学