科研之友
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摘要
Background: CD99 is involved in the intracellular transport of human leukocyte antigen class II (HLA-II) protein. The aim of this study was to clarify the clinical value of CD99 and HLA-II expression in primary osteosarcoma. Methods: One hundred and thirty pairs of osteosarcoma and matched noncancerous bone-tissues were evaluated by immunohistochemistry for CD99 and HLA-II expression. Results: Compared with the noncancerous bone tissues, the expression levels of CD99 (tumor versus normal: 2.96 +/- 0.09 versus 5.89 +/- 1.26, P<0.001) and HLA-II (tumor versus normal: 5.01 +/- 1.39 versus 1.92 +/- 0.06, P<0.001) proteins were respectively downregulated and upregulated in osteosarcoma tissues. CD99 and HLA-II were highly expressed in 49/130 (37.69%) and 107/130 (82.31%) of osteosarcoma tissues, respectively. In addition, the osteosarcoma patients with downregulation of CD99 and upregulation of HLA-II more frequently showed the presence of metastasis and recurrence and poor response to chemotherapy. Moreover, there was a negative correlation between CD99 and HLA-II expression in osteosarcoma tissues (r=-0.69, P=0.01). The patients with low CD99 expression correlated with poor prognosis of osteosarcoma, as opposed to HLA-II. Patients with CD99-low/HLA-II-high expression had the lowest overall and disease-free survival rates, and conjoined expression of CD99/HLA-II was an independent prognostic indicator of osteosarcoma. Conclusion: These findings suggest for the first time that CD99 downregulation or HLA-II upregulation may be an important feature of human osteosarcoma. The combined detection of CD99/HLA-II coexpression may present a predictive and prognostic indicator in osteosarcoma.
- 出版日期2014
- 单位徐州医科大学
