A Wet-Lab Approach to Stereochemistry Using P-31 NMR Spectroscopy

作者：Fenton Owen S; Sculimbrene Bianca R^*

来源：Journal of Chemical Education, 2011, 88(5): 662-664.

DOI：10.1021/ed100030b

• Second-Year Undergraduate
• Upper-Division Undergraduate Organic Chemistry
• Laboratory Instruction
• Hands-On Learning/Manipulatives
• Stereochemistry
• Enantiomers
• Diastereomers
• NMR Spectroscopy
• Synthesis

Understanding stereochemistry is an important and difficult task for students to master in organic chemistry. In both introductory and advanced courses, students are encouraged to explore the spatial relationships between molecules, but this exploration is often limited either to the lecture hall or the confines of the library. As such, we sought to develop an experiment-based approach that would facilitate investigation of stereochemical principles in an organic chemistry laboratory. Herein is reported a P-31 NMR-based experiment that allows students to explore the different stereochemical outcomes when enantiopure or racemic alcohols are coupled to an achiral phosphorous center.

• 出版日期2011-5