Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams

作者：Singhal Pooja; Rodriguez Jennifer N; Small Ward; Eagleston Scott; de Water Judy Van; Maitland Duncan J^*; Wilson Thomas S

来源：Journal of Polymer Science Part B: Polymer Physics , 2012, 50(10): 724-737.

DOI：10.1002/polb.23056

• aneurysm
• low density foams
• polyurethane
• secondary-shape forming
• shape memory polymer

We report the development of highly chemically crosslinked, ultra low density (similar to 0.015 g/cc) polyurethane shape memory foams synthesized from symmetrical, low molecular weight, and branched hydroxyl monomers. Sharp single glass transitions (Tg) customizable in the functional range of 4570 degrees C were achieved. Thermomechanical testing confirmed shape memory behavior with 9798% shape recovery over repeated cycles, a glassy storage modulus of 200300 kPa, and recovery stresses of 515 kPa. Shape holding tests under constrained storage above the Tg showed stable shape memory. A high volume expansion of up to 70 times was seen on actuation of these foams from a fully compressed state. Low in vitro cell activation induced by the foam compared with controls demonstrates low acute bio-reactivity. We believe these porous polymeric scaffolds constitute an important class of novel smart biomaterials with multiple potential applications.

• 出版日期2012-5-15