Association of STXBP4/COX11 rs6504950 (G > A) Polymorphism with Breast Cancer Risk: Evidence from 17,960 Cases and 22,713 Controls

作者：Tang Lin; Xu Jing; Wei Feng; Wang Li; Nie Wei Wei; Chen Long Bang; Guan Xiao Xiang^*

来源：Archives of Medical Research, 2012, 43(5): 383-388.

DOI：10.1016/j.arcmed.2012.07.008

• STXBP4/COX11
• Breast cancer
• Genetic
• Polymorphisms
• Mutation
• Risk

Background and Aims. Epidemiological studies have investigated the association between STXBP4/COX11 rs6504950 (G > A) polymorphism and breast cancer susceptibility. However, the results are still controversial. Hence, we conducted a meta-analysis of the S7XBP4/COX11 polymorphism and risk of breast cancer to obtain the most reliable estimate of the association.
Methods. PubMed, Embase and Web of Science databases were searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between STXBP4/COX11 rs6504950 (G > A) polymorphism with breast cancer risk.
Results. A total of four eligible studies including 17,960 cases and 22,713 controls based on the search criteria were involved in this meta-analysis. The distributions of genotypes in the controls were all in agreement with Hardy-Weinberg equilibrium. We observed that STXBP4/COX11 rs6504950 polymorphism was significantly correlated with breast cancer risk when all studies were pooled into the meta-analysis (the allele contrast model: OR = 0.93, 95% CI = 0.87-0.99; the heterozygote codominant model: OR = 0.87, 95% CI = 0.83-0.90; the dominant model OR = 0.92, 95% CI = 0.88-0.96).
Conclusion. This meta-analysis indicated that the rs6504950 AA/AG genotypes are associated with a significantly decreased risk of breast carcinogenesis.

• 出版日期2012-7
• 单位南京大学