Aspirin degradation in surface-charged TEMPO-oxidized mesoporous crystalline nanocellulose

作者：Carlsson Daniel O; Hua Kai; Forsgren Johan^*; Mihranyan Albert

来源：International Journal of Pharmaceutics, 2014, 461(1-2): 74-81.

DOI：10.1016/j.ijpharm.2013.11.032

• Nanocellulose
• Cladophora cellulose
• TEMPO-mediated oxidation
• Mesoporous materials
• Chemical stability

TEMPO-mediated surface oxidation of mesoporous highly crystalline Cladophora cellulose was used to introduce negative surface charges onto cellulose nanofibrils without significantly altering other structural characteristics. This enabled the investigation of the influence of mesoporous nanocellulose surface charges on aspirin chemical stability to be conducted. The negative surface charges (carboxylate content 0.44 +/- 0.01 mmol/g) introduced on the mesoporous crystalline nanocellulose significantly accelerated aspirin degradation, compared to the starting material which had significantly less surface charge (0.06 +/- 0.01 mmol/g). This effect followed from an increased aspirin amorphisation ability in mesopores of the oxidized nanocellulose. These results highlight the importance of surface charges in formulating nanocellulose for drug delivery.

• 出版日期2014-1-30