An Overview of Naturally Occurring Histone Deacetylase Inhibitors

作者：Kim Bumki; Hong Jiyong^*

来源：Current Topics in Medicinal Chemistry, 2014, 14(24): 2759-2782.

• Epigenetics
• Histone deacetylase inhibitor
• Histone modification
• Isoform selectivity
• Natural product

Histone deacetylases (HDACs) have recently emerged as key elements in epigenetic control of gene expression. Due to the implication of HDACs in a variety of diseases ranging from cancer to neurodegenerative disorder, HDAC inhibitors have received increased attention in recent years. Over the last few decades, a myriad of HDAC inhibitors containing a wide variety of structural features have been identified from natural sources. Here, we review the discovery, synthesis, biological properties, and modes of action of these naturally occurring HDAC inhibitors and consider their implications for future research.

• 出版日期2014