科研之友
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摘要
To investigate the use of root mean square displacement (RMSD) and mean diffusional kurtosis (DK) metrics of q-space imaging data to estimate spinal cord compression in patients with early cervical spondylosis. %26lt;br%26gt;We studied 50 consecutive patients at our institution (22 male, 28 female; mean age 58 years; age range 20-86 years) who had clinical signs and symptoms suggestive of early clinical stage cervical myelopathy. After conventional magnetic resonance (MR) imaging, diffusion tensor and q-space image data were acquired using 3-T MR imaging. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), RMSD and mean DK values were calculated and compared between compressed and uncompressed spinal cords. %26lt;br%26gt;FA and mean DK values were significantly lower and RMSD was significantly higher (P = 0.0060, 0.0020 and 0.0062, respectively; Mann-Whitney U test with the Bonferroni correction) in compressed spinal cords than in uncompressed cords. ADC was also higher in compressed cords, but this difference was not statistically significant. %26lt;br%26gt;In the evaluation of spinal cord damage in early cervical spondylosis, mean DK and RMSD values in the spinal cord may be highly sensitive indicators of microstructural change and damage. %26lt;br%26gt;aEuro cent Absolute surgical indications for cervical spondylosis with myelopathy remain to be established. %26lt;br%26gt;aEuro cent Diffusion tensor MRI shows abnormalities in normal-appearing but compressed spinal cord. %26lt;br%26gt;aEuro cent Non-Gaussian diffusion analysis is highly sensitive in revealing spinal cord damage.
- 出版日期2012-8
