Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

作者：Stephens Andrew D; Liu Patrick Z; Banigan Edward J; Almassalha Luay M; Backman Vadim; Adam Stephen A; Goldman Robert D; Marko John F

来源：Molecular Biology of the Cell, 2018, 29(2): 220-233.

DOI：10.1091/mbc.E17-06-0410

<jats:p> Chromatin decompaction via increasing euchromatin or decreasing heterochromatin results in a softer nucleus and abnormal nuclear blebbing, independent of lamin perturbations. Conversely, increasing heterochromatin stiffens the nucleus and rescues nuclear morphology in lamin-perturbed cells that present abnormal nuclear morphology. </jats:p>

• 出版日期2018-1-15