科研之友
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摘要
Introduction: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction.
Methods: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a doubleblind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed. Thirtyfive participants completed resting-state functional magnetic resonance imaging (MRI) scans before and after training.
Results: ABM significantly mitigated an anxious traits regarding physical stress vulnerability (eta(2)= 0.12, p=0.009). As compared to sham training, ABM significantly strengthened FC between the pulvinar and transverse temporal gyrus along the temporoparietal junction (T=3.90, (FDR-corrected) p=0.010), whereas it decreased FC between the postCG and ventral fronto-parietal network (vFPN) regions such as the anterior insula and ventrolateral prefrontal cortex (all T <=-3.19, (FDR-corrected) p=0.034). Although ABM diminished network measures of the postcentral gyrus (postCG) (all T <=-4.30, (FDR-corrected) p=0.006), only the pulvinar-related FC increase was specifically correlated with anxiety reduction (r=-0.46, p=0.007).
Limitations: Per-protocol analysis and reduced sample size in MRI analysis.
Conclusions: ABM might augment the pulvinar's control over vFPN to maintain endogenous attention to a behavioral goal, while diminishing the information exchanges of the postCG with vFPN to inhibit the capture of exogenous attention by potential threats. The pulvinar might play a critical role in ABM anxiolytic efficacy.<=
- 出版日期2018-10-1
