Anti-Mullerian hormone concentrations and antral follicle counts for the prediction of pregnancy outcomes after intrauterine insemination

作者：Moro Francesca^*; Tropea Anna; Scarinci Elisa; Leoncini Emanuele; Boccia Stefania; Federico Alex; Alesiani Ornella; Lanzone Antonio; Apa Rosanna

来源：International Journal of Gynecology & Obstetrics, 2016, 133(1): 64-68.

DOI：10.1016/j.ijgo.2015.08.021

• Anti-Millierian hormone
• Antral follicle count
• Intrauterine insemination
• Ovulation induction
• Prediction

Objective: To evaluate anti-Mullerian hormone (AMH) concentrations and antral follicle counts (AFCs) in the prediction of pregnancy outcomes after controlled ovarian stimulation among women undergoing intrauterine insemination. Methods: A retrospective study included women with unexplained infertility aged 41 years or younger who attended a fertility clinic in Italy between December 2009 and May 2014. Ovarian stimulation was achieved with recombinant follicle-stimulating hormone or highly purified human menopausal gonadotropin. Receiver operating characteristic curves were generated to predict ongoing pregnancy. The primary outcome was the association between AMH/AFC and ongoing pregnancy, and was assessed by logistic regression. Results: Overall, 276 women were included, of whom 43 (15.6%) achieved ongoing pregnancy. Multivariate analysis showed that women with a serum day-3 concentration of AMH higher than 23 ng/mL were more likely to have ongoing pregnancy than were those with a concentration lower than 23 ng/mL (odds ratio 5.84, 95% confidence interval 238-14.31; P < 0.001). No associations were recorded for AFCs. Conclusion: AMH should be used to predict the pregnancy outcome of intrauterine insemination.

• 出版日期2016-4