Assessing Medication Adherence of Perinatally HIV-Infected Children Using Caregiver Interviews

作者：Allison Susannah M^*; Koenig Linda J; Marhefka Stephanie L; Carter Rosalind J; Abrams Elaine J; Bulterys Marc; Tepper Vicki; Palumbo Paul E; Bachanas Pamela J; Farley John J

来源：Journal of the Association of Nurses in AIDS Care, 2010, 21(6): 478-488.

DOI：10.1016/j.jana.2010.02.006

• adherence assessment
• HIV disease
• knowledge of prescribed dosing frequency
• pediatrics

Medication adherence is critical for children's HIV treatment success, but obtaining accurate assessments is challenging when complex measurement technologies are not feasible. Our goal was to evaluate a multidimensional adherence interview designed to improve on existing adherence measures. Data from caregivers (N = 126) of perinatally infected children were analyzed to determine the ability of the revised interview guide to detect potential treatment nonadherence. Questions related to viral load (VL) on a bivariate level included proportion of doses taken in the previous 3 days and 6 months, caregivers' knowledge of prescribed dosing frequencies, and caregivers' reports of problems associated with medication administration. VL was not associated with 3-day recall of missed doses. In multivariate analyses, only caregivers' knowledge of prescribed dosing frequencies was uniquely associated with VL. Our modified interview appears to successfully identify family struggles with adherence and to have the capacity to help clinicians address medication adherence challenges.

• 出版日期2010-12