Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

作者：Acosta Andres; Camilleri Michael^*; Shin Andrea; Carlson Paula; Burton Duane; O'Neill Jessica; Eckert Deborah; Zinsmeister Alan R

来源：Genes and Nutrition, 2014, 9(2): 384.

DOI：10.1007/s12263-014-0384-8

• Melanocortin 4 receptor (MC4R)
• rs17782313
• Satiation
• Gastric emptying
• Obesity

Melanocortin 4 receptor (MC4R) has a major role in energy homeostasis. The rs17782313 polymorphism, mapped 188 kb downstream from MC4R, has been associated with satiety, higher body mass index (BMI) and total calorie intake in adults. To assess the association of rs17782313 with gastric functions, satiation, or satiety, we studied 178 predominantly Caucasian overweight and obese people: 120 females, 58 males; mean BMI 33.4 +/- 5.3 kg/m(2) (SD); age 37.7 +/- 11.2 years. Quantitative traits assessed were gastric emptying (GE) of solids and liquids; fasting and postprandial gastric volume; satiation by maximum tolerated volume and 4 symptoms by 100-mm visual analog scales (VAS); and satiety by ad libitum buffet meal. Associations of genotype and quantitative traits were assessed by analysis of covariance (using gender and BMI as covariates), based on a dominant [TC (n = 72) - CC (n = 12) vs. TT (n = 94)] genetic model. rs17782313(C) was associated with postprandial satiation symptoms (median Delta total VAS 26.5 mm, p = 0.036), reduced proportion of solid GE at 2 h (median Delta 6.7 %, p = 0.008) and 4 h (median Delta 3.2 %, p = 0.006), and longer t(1/2) (median Delta 6 min, p = 0.034). Associations of rs17782313 with obesity may be explained by reduced satiation and GE. The role of MC4R mechanisms in satiation and gastric function deserves further study.

• 出版日期2014-3