Altered Spatiotemporal Dynamics of the Mitochondrial Membrane Potential in the Hypertrophied Heart

作者：Jin Hongwei; Nass Robert D; Joudrey Paul J; Lyon Alexander R; Chemaly Elie R; Rapti Kleopatra; Akar Fadi G^*

来源：Biophysical Journal, 2010, 98(10): 2063-2071.

DOI：10.1016/j.bjp.2010.01.045

Chronically elevated levels of oxidative stress resulting from increased production and/or impaired scavenging of reactive oxygen species are a hallmark of mitochondrial dysfunction in left ventricular hypertrophy. Recently, oscillations of the mitochondrial membrane potential (Delta Psi(m)) were mechanistically linked to changes in cellular excitability under conditions of acute oxidative stress produced by laser-induced photooxidation of cardiac myocytes in vitro. Here, we investigate the spatiotemporal dynamics of Delta Psi(m) within the intact heart during ischemia-reperfusion injury. We hypothesize that altered metabolic properties in left ventricular hypertrophy modulate Delta Psi(m) spatiotemporal properties and arrhythmia propensity.

• 出版日期2010-5-19