A case of metronidazole-resistant Trichomonas vaginalis in pregnancy

作者：Forbes Georgina L^*; Drayton Rachel; Forbes Gavin D

来源：International Journal of STD & AIDS, 2016, 27(10): 906-908.

DOI：10.1177/0956462415601295

• Trichomonas vaginalis
• T
• Vaginalis
• trichomoniasis
• sexually transmitted infection
• pregnancy
• metronidazole
• resistance

Trichomonas vaginalis is a sexually transmitted protozoan infection resulting in vulvo-vaginitis and altered vaginal discharge in symptomatic women. Trichomoniasis has been implicated in causing adverse pregnancy outcomes such as low birth weight and pre-term labour. Metronidazole is the recommended first-line treatment for trichomonal infection. Other nitroimidazoles, such as tinidazole, are used as alternative regimens with similar activity but at a greater expense. Treatment failure usually represents patient non-compliance or re-infection, although metronidazole resistance has previously been documented. Antimicrobial susceptibility testing for T. vaginalis is currently not available in the UK. Patients with disease unresponsive to first-line treatments pose a major challenge, as therapeutic options are limited. We present the case of a patient with presumed resistant infection during pregnancy, and the additional treatment issues that this presented.

• 出版日期2016-9