Association of Single Nucleotide Polymorphism in Bone Morphogenetic Protein Receptor 1B (BMPR-1B) Gene with Growth Traits in Chicken

作者：Awad Ashraf; El Tarabany Mahmoud Salah^*

来源：Kafkas Universitesi Veteriner Fakultesi Dergisi, 2015, 21(6): 819-824.

DOI：10.9775/kvfd.2015.13515

• Chicken
• BMPR-1B
• SNP
• Growth traits

Growth traits are under the control of multiple genes. Understanding the genetic information of related genes is helpful for the selection and breeding course through marker assisted selection. The aim of the current study was to investigate the association of A287G SNP in BMPR-1B gene with growth traits in chicken. A single nucleotide polymorphism was identified in 240 individuals using the PCR-RFLP technique and confirmed by sequencing. The allelic and genotypic frequencies were compared, using the Chi-squared test. Associations between the genotype of each polymorphism and the traits were analyzed using the General Linear Model of statistical software SAS. Three genotypes (AA, AG and GG) were detected in Fayoumi and Rhold Island Red chicken. Sequencing revealed one mutation (287 A -> G) in the genotype AA in comparison to the genotype GG. The A287G SNP of BMPR-1B gene was associated significantly with body weight at 2nd (P=0.022), 3rd (P=0.034), 4th (P=0.011), 5th (P=0.035), 6th (P=0.001), 7th (P=0.008) and 8th (P=0.016) week of age. In conclusion, BMPR-1B gene may be associated with body weight in chicken and may be considered in Marker Assisted Selection program to improve chicken growth performance.

• 出版日期2015-12