A new cembrane-type diterpenoid from Bornean liverwort Chandonanthus hirtellus

作者:Ng Shean Yeaw; Kamada Takashi; Suleiman Monica; Vairappan Charles S*
来源:Journal of Asian Natural Products Research, 2016, 18(7): 690-696.
DOI:10.1080/10286020.2015.1134503

摘要

A new compound, chandonanol (1), along with four known compounds, chandonanthone (2), iso-chandonanthone (3), anastreptene (4), and (6R,7S)-sesquiphellandrene (5), was isolated from the MeOH extract of Bornean liverwort Chandonanthus hirtellus. The structure of the new metabolite was established by analyses of the spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). These compounds were tested for their activity against antibiotic-resistant clinical strains. Chandonanol (1) exhibited potent bactericidal activity against Staphylococcus aureus and Escherichia coli.

  • 出版日期2016