A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends

作者:Wilsdorf M; Schmidt D; Bartetzko M P; Dallabernardina P; Schuhmacher F; Seeberger P H; Pfrengle F*
来源:Chemical communications, 2016, 52(66): 10187-10189.
DOI:10.1039/c6cc04954k

摘要

We report a traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends. The reductive-labile functionality in the linker tolerates all commonly used reagents and protocols for automated glycan assembly, as demonstrated with the successful preparation of nine plant cell wall-related oligosaccharides, and is cleaved by hydrogenolysis.

  • 出版日期2016-8-25