Association between HLA-B*15:02 and oxcarbazepine-induced cutaneous adverse reaction: a meta-analysis

作者：Liu, Yiwei; Yu, Yuncui; Nie, Xiaolu; Zhao, Libo^*; Wang, Xiaoling^*

来源：Pharmacogenomics, 2018, 19(6): 547-552.

DOI：10.2217/pgs-2017-0189

• cutaneous adverse reaction
• HLA-B*15:02
• oxcarbazepine

Aim: HLA-B*15: 02 has been demonstrated as a key risk factor for carbamazepine-induced severe cutaneous adverse reaction (sCAR), especially in Asian population. Oxcarbazepine (OXC) is a drug that has a similar structure of carbamazepine. However, the relationship between HLA-B*15: 02 and induced cutaneous adverse reaction (cADR) remains unknown. This study aims to analyze this association in the published literature. Method: After filtering studies, eight studies were finally included for meta-analysis, including 32 sCAR cases, 112 mild cutaneous adverse reaction (mcADR) cases, 281 OXC tolerant control and 946 population control cases. Result: In the tolerant control group, an association was found between HLA-B* 15: 02 genotype and OXC-induced sCAR (odds ratio [OR]: 18.13; 95% CI: 6.77-48.56), but not in mcADR (OR: 1.43; 95% CI: 0.56-3.64). In population control group, an association was found between HLA-B* 15: 02 genotype and OXC-induced sCAR, (OR: 8.22; 95% CI: 3.03-22.34), but not in mcADR (OR: 2.06; 95% CI: 0.91-4.67). Discussion: Our study demonstrates that the genetic risk factor HLA-B* 15: 02 may be a factor in OXC-induced sCAR.

• 出版日期2018-4
• 单位首都医科大学