A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex

作者：Wang Jintao; Lu Kaihui; Xuan Shuguang; Toh Zaozhen; Zhang Dawei^*; Shao Fangwei

来源：Chemical communications, 2013, 49(42): 4758-4760.

DOI：10.1039/c3cc40868j

A new G-quadruplex (GQ) stabilizer, [Pt(Dip)(2)](PF6)(2) (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ.

• 出版日期2013
• 单位南阳理工学院