An Evaluation of Treatment Strategies for Head and Neck Cancer in an African American Population

作者：Ignacio D N^*; Griffin J J; Daniel M G; Serlemitsos Day M T; Lombardo F A; Alleyne T A

来源：West Indian Medical Journal, 2013, 62(6): 504-509.

DOI：10.7727/wimj.2013.04

• African American
• cetuximab
• combination-therapy
• head and neck cancer
• survival

Objective: This study evaluated treatment strategies for head and neck cancers in a predominantly African American population. %26lt;br%26gt;Methods: Data were collected utilizing medical records and the tumour registry at the Howard University Hospital. Kaplan-Meier method was used for survival analysis and Cox proportional hazards regression analysis predicted the hazard of death. %26lt;br%26gt;Results: Analysis revealed that the main treatment strategy was radiation combined with platinum for all Stages except stage I. Cetuximab was employed in only 1% of cases. Kaplan-Meier analysis revealed stage II patients had poorer outcome than stage IV while Cox proportional hazard regression analysis (p = 0.4662) showed that stage I had a significantly lower hazard of death than stage IV (HR = 0.314; p = 0.0272). Contributory factors included tobacco and alcohol but body mass index (BMI) was inversely related to hazard of death. %26lt;br%26gt;Conclusions: There was no difference in survival using any treatment modality for African Americans.

• 出版日期2013-7