科研之友
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摘要
A metal-free, open-flask protocol was developed for the preparation of allylic sulfones through direct condensation of sodium arylsulfinates and beta,beta/3-disubstituted nitroalkenes. The key step of this process was the Lewis base-promoted equilibrium between nitroalkenes and allylic nitro compounds. Through this process, the readily available conjugated nitroalkenes can be easily converted into allylic nitro compounds, which contain more reactive C=C bonds toward the sulfonyl radical addition. As a result, allylic broad substrate scope under mild conditions. sulfones were prepared in excellent yields with a broad substrate scope under mild conditions.
- 出版日期2018-2-16
- 单位武汉工程大学
