Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kolliker's organ in vivo in early stage after birth in rats

作者：Liu, Jun; Cai, Linbin; He, Yuanyuan; Yang, Jun^*

来源：European Journal of Histochemistry, 2017, 61(3): 171-177.

DOI：10.4081/ejh.2017.2706

• Kolliker's organ
• supporting cells
• apoptosis
• development

Kolliker's organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5'-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kolliker's organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kolliker's organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kolliker's organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3. This study demonstrates a time-dependent degeneration of Kolliker's organ during postnatal cochlea development, which might be triggered by endogenous factors.

• 出版日期2017
• 单位上海交通大学