An aggregation-induced emission-based pH-sensitive fluorescent probe for intracellular acidity sensing

作者：Lin, Na; Chen, Xiaohong; Yan, Shuanghong; Wang, Han; Lu, Zhixiang; Xia, Xin; Liang, Mengyu; Wu, Yun-Long^*; Zheng, Liyan^*; Cao, Qiue^*; Ding, Zhongtao

来源：RSC Advances, 2016, 6(30): 25416-25419.

DOI：10.1039/c6ra01167e

• LIGHT-UP PROBE
• GRAPHENE OXIDE
• CELLS
• NANOCLUSTERS
• APOPTOSIS
• FLUOROGEN
• STRATEGY
• SENSOR
• RANGE

A dual-emission pH-sensitive fluorescent probe was developed, which displays green fluorescence in alkaline after deprotonation, while orange emission in acid at aggregated state. This novel probe allows the specific light-on in acidic lysosomes of cancer cells and tumors in nude mice, which indicates its potential application in cancer diagnosis.

• 出版日期2016
• 单位厦门大学; 云南大学