Update on topical glucocorticoid use in children

作者：Morley Keith W; Dinulos James G^*

来源：Current Opinion in Pediatrics, 2012, 24(1): 121-128.

DOI：10.1097/MOP.0b013e32834ef53d

• corticosteroids
• steroid allergy
• steroid phobia
• steroid potency
• topical glucocorticoids

Purpose of review %26lt;br%26gt;This monograph reviews recent studies, examining topical glucocorticoid use in children. Emphasis is placed on mechanism of action, relative potency, cutaneous absorption, adverse affects, steroid phobia, and treatment compliance. %26lt;br%26gt;Recent findings %26lt;br%26gt;Recent literature has shown that over 80% of patients prescribed topical glucocorticoids are fearful of side effects and fail to use them appropriately. This lack of compliance leads to decreased therapeutic benefits. Despite this %26apos;steroid phobia%26apos;, multiple studies indicate that proper use of glucocorticoids in children is well tolerated and effective. Recent studies have failed to show clinically significant hypothalamic-pituitary-adrenal suppression and cutaneous atrophy in children. High-potency steroids have been shown to cause growth restriction when used during pregnancy. Steroid allergy occurs with a prevalence of 2.7% and should be considered in children who fail to respond as expected to topical glucocorticoids. %26lt;br%26gt;Summary %26lt;br%26gt;Topical glucocorticoids continue to be well tolerated, effective and cost-effective in the treatment of inflammatory cutaneous conditions in children.

• 出版日期2012-2