Acylation Stimulating Protein, Complement C3 and Lipid Metabolism in Ketosis-Prone Diabetic Subjects

作者：Liu Yan; Gupta Priyanka; Lapointe Marc; Yotsapon Thewjitcharoen; Sarat Sunthornyothin; Cianflone Katherine^*

来源：PLos One, 2014, 9(10): e109237.

DOI：10.1371/journal.pone.0109237

Background: Ketosis-prone diabetes (KPDM) is new-onset diabetic ketoacidosis without precipitating factors in non-type 1 diabetic patients; after management, some are withdrawn from exogenous insulin, although determining factors remain unclear. %26lt;br%26gt;Methods: Twenty KPDM patients and twelve type 1 diabetic patients (T1DM), evaluated at baseline, 12 and 24 months with/without insulin maintenance underwent a standardized mixed-meal tolerance test (MMTT) for 2 h. %26lt;br%26gt;Results: At baseline, triglyceride and C3 were higher during MMTT in KPDM vs. T1DM (p%26lt;0.0001) with no differences in non-esterified fatty acids (NEFA) while Acylation Stimulating Protein (ASP) tended to be higher. Within 12 months, 11 KPDM were withdrawn from insulin treatment (KPDM-ins), while 9 were maintained (KPDM+ins). NEFA was lower in KPDM-ins vs. KPDM+ins at baseline (p = 0.0006), 12 months (p%26lt;0.0001) and 24 months (p%26lt;0.0001) during MMTT. NEFA in KPDM-ins decreased over 30-120 minutes (p, 0.05), but not in KPDM+ins. Overall, C3 was higher in KPDM-ins vs KPDM+ins at 12 months (p = 0.0081) and 24 months (p = 0.0019), while ASP was lower at baseline (p = 0.0024) and 12 months (p = 0.0281), with a decrease in ASP/C3 ratio. %26lt;br%26gt;Conclusions: Notwithstanding greater adiposity in KPDM-ins, greater NEFA decreases and lower ASP levels during MMTT suggest better insulin and ASP sensitivity in these patients.

• 出版日期2014-10-2
• 单位华中科技大学