A noncontact fluorescence tomography system based on time-correlated single photon counting technique

作者：Zhao Hui Juan^*; Wang Ting Ting; Li Jiao; Gao Feng

来源：Nanotechnology and Precision Engineering, 2012, 10(3): 243-248.

• Breast imaging
• Contact effect
• Conventional measurements
• Double target
• Early breast cancer
• Edge distance
• Fluorescence tomography
• In-vivo
• Non-contact
• Non-contact detection
• Quantitative experiments
• Solid phantoms
• Spatial resolution
• Time domain
• Time-correlated single photon counting techniques

A time domain fluorescence tomography system for the diagnosis of early breast cancer was developed based on the time-correlated single photon counting(TCSPC) technique. Noncontact scanning scheme was adopted to fit in-vivo breast imaging. Compared with conventional measurement, noncontact detection offers sufficient sampling of photon signals while avoiding fiber-tissue contact effects, the spatial resolution can be improved. The performance and efficacy of the system was assessed by solid phantom experiments. Results show that when the phantom has one target, the fluorescent yield and lifetime can be reconstructed with good accuracy; when the phantom has double targets with the center-to-center spacing of 20 mm and the edge distance of 15 mm, the targets can be differentiated from the yield image. Quantitative experiments show that the results achieve good linearity. The system can be further developed to be applied to clinical breast imaging.

• 出版日期2012
• 单位天津大学