Amidation Reaction of Carboxylic Acid with Formamide Derivative Using SO3 center dot pyridine

作者：Kawano Shota; Saito Kodai; Yamada Tohru^*

来源：Chemistry Letters, 2018, 47(4): 584-586.

DOI：10.1246/cl.171216

• Amidation
• Sulfur oxide
• Metal-free synthesis

The amidation reaction of carboxylic acid derivatives was developed using sulfur trioxide pyridine complex (SO3 center dot py) as a commercially available and easily handled oxidant. This method could be applied to the reaction of various aromatic and aliphatic carboxylic acids, including optically active ones, with formamide derivatives to afford the corresponding amides in good to high yields.

• 出版日期2018-4