Antitussive activity of polysaccharides isolated from the Malian medicinal plants

作者：Sutovska M; Franova S; Priseznakova L; Nosal'ova G; Togola A; Diallo D; Paulsen B S; Capek P^*

来源：International Journal of Biological Macromolecules, 2009, 44(3): 236-239.

DOI：10.1016/j.ijbiomac.2008.12.013

• Malian medicinal plants
• Trichilia emetica
• Opilia celtidifolia
• Crossopteryx febrifuga
• Polysaccharides
• Antitussive activity
• Cough

From the leaves of popular Malian medicinal plants Trichilia emetica (TE) and Opilia celtidifolia (OC), and fruits of Crossoptetyx febrifuga (CF) water and water-ethanol soluble polysaccharide materials were isolated. The results of chemical analysis of the crude polysaccharides showed the dominance of the arabinogalactan (similar to 54%) and the rhamnogalacturonan (similar to 30%) in T emetica leaves, the arabinogalactan (similar to 60%), the rhamnogalacturonan (similar to 14%) and the glucuronoxylan (similar to 14%) in O. celtidifolia leaves, and pectic type of polysaccharicles (similar to 75%) with a lower content of the arabinogalactan (similar to 17%) in C.febrifuga fruits. The plant polysaccharicles showed various biological effects on the citric acid-induced cough reflex and reactivity of airways smooth muscle in vivo conditions. T emetica and O. celtidifolia polysaccharides possessed significant cough-suppressive effect on chemically induced cough. Furthermore, values of specific airways resistance pointed on bronchodilatory property of polysaccharides isolated from O. celtidifolia. However, the crude extract from C.febrifuga in the same dose as T emetica and O. celtidifolia did not influence the experimentally induced cough as well as reactivity of airways smooth muscle despite of the fact that the water-ethanol extract is recommended for cough therapy in Mali in the form of syrup.

• 出版日期2009-4-1