NF-kappa B in innate neuroprotection and age-related neurodegenerative diseases

作者：Lanzillotta Annamaria; Porrini Vanessa; Bellucci Arianna; Benarese Marina; Branca Caterina; Parrella Edoardo; Spano Pier Franco; Pizzi Marina^*

来源：Frontiers in Neurology, 2015, 6: UNSP 98.

DOI：10.3389/fneur.2015.00098

• NF-kappa B
• epigenetic drugs
• BDNF
• c-Rel deficient mice
• RelA (K310)

NF-kappa B factors are cardinal transcriptional regulators of inflammation and apoptosis, involved in the brain programing of systemic aging and in brain damage. The composition of NF-kappa B active dimers and epigenetic mechanisms modulating histone acetylation, finely condition neuronal resilience to brain insults. In stroke models, the activation of NF-kappa B/c-Rel promotes neuroprotective effects by transcription of specific anti-apoptotic genes. Conversely, aberrant activation of NF-kappa B/RelA showing reduced level of total acetylation, but site-specific acetylation on lysine 310, triggers the expression of proapoptotic genes. Constitutive knockout of c-Rel shatters the resilience of substantia nigra (SN) dopaminergic (DA) neurons to aging and induces a parkinsonian like pathology in mice. c-rel(-/-) mice show increased level of aberrantly acetylated RelA in the basal ganglia, neuroinflammation, accumulation of alpha-synuclein, and iron. Moreover, they develop motor deficits responsive to L-DOPA treatment and associated with loss of DA neurons in the SN. Here, we discuss the effect of unbalanced activation of RelA and c-Rel during aging and propose novel challenges for the development of therapeutic strategies in neurodegenerative diseases.

• 出版日期2015-5-20