A Facile and Mild Approach for Stereoselective Synthesis of alpha-Fluoro-alpha,beta-unsaturated Esters from alpha-Fluoro-beta-keto Esters via Deacylation

作者：Qian Jinlong; Yi Wenbin^*; Lv Meifang; Cai Chun

来源：Synlett, 2015, 26(1): 127-132.

DOI：10.1055/s-0034-1378917

• olefination
• highly stereoselective
• deacylation
• fluoroolefins
• carbon-carbon bond cleavage

The highly stereoselective olefination reaction of alpha-fluoro-beta-keto esters for the synthesis of alpha-fluoro-alpha,beta-unsaturated esters has been developed. The olefination combines nucleophilic addition, intramolecular nucleophilic addition, and elimination in one step, as well as provides a facile synthetic approach to alpha-fluoro-alpha,beta-unsaturated esters which are important units in many biologically active compounds and useful precursors in a variety of functional-group transformations.

• 出版日期2015-1
• 单位南京理工大学