A study on relationship between elderly sarcopenia and inflammatory factors IL-6 and TNF-alpha

作者：Bian, Ai-Lin^*; Hu, Hui-Ying; Rong, Yu-Dong; Wang, Jian; Wang, Jun-Xiong; Zhou, Xin-Zi

来源：European Journal of Medical Research, 2017, 22(1): 25.

DOI：10.1186/s40001-017-0266-9

• Elders
• Skeletal muscle reduction
• IL-6
• TNF-alpha

Background: This report aims to study the relationship between sarcopenia of elderly in community and inflammatory factors IL-6 and TNF-alpha.
Methods: A total of 441 elders who undertook physical examinations were included into this study. The age of these subjects were >60, in which 235 subjects were male and 206 subjects were female. According to the diagnostic standards of sarcopenia set by EWGSOP and AWGS, these subjects were divided into two groups: sarcopenia, and non-sarcopenia groups. The living habits, disease status, biochemical indexes, and levels of IL-6 and TNF-alpha of these subjects were investigated.
Results: The morbidity rate of sarcopenia was 17.02% in male subjects and 18.9% in female subjects. In elderly subjects >80 years old, morbidity rate was 25.3% in male subjects and 35.1% in female subjects. The history of smoking in patients with sarcopenia was long, and their regular exercise history was short (P < 0.01). Furthermore, differences in handgrip strength (HG), fat-free mass (FFM), bone mineral content (BMC), plasma albumin (ALB) and serum creatinine (Cr), and body fat content (FAT) in patients between the sarcopenia and non-sarcopenia groups were statistically significant (P < 0.05). Moreover, differences in IL-6 and TNF-alpha levels between these two groups were statistically significant (P < 0.05). In addition, BMI was positively correlated to TNF-alpha levels, and ALB was negatively correlated to IL-6; while BMI and VFA were positively correlated to TNF-alpha levels, and SMM, HDL-C, Hb, HG were negatively correlated to IL-6 level (P < 0.05). Multiple linear regression analysis suggested plasma ALB and BMI were the independent risk factors of TNF-alpha, while VFA was the independent risk factor of IL-6.
Conclusions: The onset of sarcopenia was associated with poor exercise habits, disease history, and nutritional status. The emergence of sarcopenia was accompanied by increased levels of inflammation factors TNF-alpha and IL-6. Plasma albumin, BMI, and VFA were inflammatory factor predictors of TNF and IL-6.

• 出版日期2017-7-12
• 单位天津市第一中心医院