Posttranslational Peptide-Modification Enzymes in Action: Key Roles for Leaders and Glutamate

作者:Montalban Lopez Manuel; Kuipers Oscar P*
来源:Cell Chemical Biology, 2016, 23(3): 318-+.
DOI:10.1016/j.chembiol.2016.03.001

摘要

In this issue of Cell Chemical Biology, Ortega et al. (2016) determine the structure of another lantibiotic dehydratase with a tRNA(Glu) dependent mechanism of modification. Moreover, they identify a common recognition motif involved in leader peptide binding in a number of different peptide-modification enzymes. These findings open up new mining possibilities and allow novel approaches in peptide engineering.

  • 出版日期2016-3-17