科研之友
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摘要
Background: Diabetes is a metabolic. disorder characterized by presence of chronic hyperglycaemia. Thus, strategies to maintain blood glucose levels are critical for the treatment of this devastating disease. Anthocyanins are naturally occurring compounds widely available in berries, and increasing evidence demonstrates a positive relationship between consumption of anthocyanins rich foods and lowers diabetes complications. @@@ Scope and approach: This review highlights recent findings on the anti-diabetic effects of anthocyanins in various organs and particularly emphasizes on the studies that investigated the cellular and molecular mechanisms involved in the beneficial effects of this bioactive molecules. @@@ Key findings and conclusions: Over the past two decades, numerous studies have demonstrated that anthocyanins can exert the beneficial effects in diabetes by acting on various molecular targets and regulate different signalling pathways in multiple organs and tissues such as liver, pancreas, kidney, adipose, skeletal muscle and brain. Anthocyanins can lower blood glucose levels by protecting beta-cells, improving insulin resistance, increasing insulin secretion, improving liver function, and inhibiting carbohydrate hydrolyzing enzymes. The antidiabetic properties of anthocyanins may also attribute to their antioxidant capacity. Taken together, anthocyanins may be a novel small molecule for the prevention and treatment of diabetes.
- 出版日期2017-10
- 单位浙江大学
