Auxiliary-Enabled Pd-Catalyzed Direct Arylation of Methylene C(sp(3))-H Bond of Cyclopropanes: Highly Diastereoselective Assembling of Di- and Trisubstituted Cyclopropanecarboxamides

作者：Parella Ramarao; Gopalakrishnan Bojan; Babu Srinivasarao Arulananda^*

来源：Organic Letters, 2013, 15(13): 3238-3241.

DOI：10.1021/ol4012212

An auxiliary-enabled and Pd(OAc)(2)-catalyzed direct arylation of C(sp(3))-H bonds of cyclopropanes and production of di- and trisubstituted cyclopropanecarboxamides having contiguous stereocenters are reported. The installation of aryl groups on cyclopropanecarboxamides led to the assembling of novel mono- and di- aryl-N-(quinolin-8-yl)cyclopropanecarboxamide scaffolds and mono- and di- aryl-N-(2-(methylthio)phenyl)cyclopropanecarboxamides. The stereochemistry of products was unequivocally assigned from the X-ray structures of key compounds.

• 出版日期2013-7-5