Analysis of optineurin in frontotemporal lobar degeneration

作者：Rollinson Sara; Bennion Janis; Toulson Greg; Halliwell Nicola; Usher Suzanne; Snowden Julie; Richardson Anna; Neary David; Mann David; Pickering Brown Stuart M^*

来源：Neurobiology of Aging, 2012, 33(2): 425.e1.

DOI：10.1016/j.neurobiolaging.2010.10.002

• Frontotemporal lobar degeneration
• FTLD
• optineurin

Frontotemporal lobar degeneration (FTLD) can occur jointly with amyotrophic lateral sclerosis (ALS), and these 2 conditions share a genetic risk factor on chromosome 9. It has been reported that mutations in optineurin (OPTN) can cause ALS. Therefore, we sequenced OPTN in 371 FTLD cases but no mutations were detected, suggesting changes in OPTN do not cause FTLD.

• 出版日期2012-2