Associations of serum LDL particle concentration with carotid intima-media thickness and coronary artery calcification

作者：Zaid Maryam^*; Miura Katsuyuki; Fujiyoshi Akira; Abbott Robert D; Hisamatsu Takashi; Kadota Aya; Arima Hisatomi; Kadowaki Sayaka; Torii Sayuki; Miyagawa Naoko; Suzuki Sentaro; Takashima Naoyuki; Ohkubo Takayoshi; Sekikawa Akira; Maegawa Hiroshi; Horie Minoru; Nakamura Yasuyuki; Okamura Tomonori; Ueshima Hirotsugu

来源：Journal of Clinical Lipidology, 2016, 10(5): 1195-1202.

DOI：10.1016/j.jacl.2015.12.027

• Low-density lipoprotein particle (LDL-P)
• Low-density lipoprotein cholesterol (LDL-C)
• Carotid intima-media thickness (cIMT)
• Coronary artery calcification (CAC)
• Subclinical atherosclerosis

BACKGROUND: Low-density lipoprotein particle (LDL-P) has recently been found to be a stronger predictor of cardiovascular disease (CVD) than LDL-cholesterol (LDL-C).
OBJECTIVES: Whether LDL-P is associated with subclinical atherosclerosis, independent of LDLC, as well as other lipid measures has not been fully examined. We aimed to analyze LDL-P associations with measures of subclinical atherosclerosis.
METHODS: We examined 870 Japanese men randomly selected from Kusatsu City, Shiga, Japan, aged 40-79 years from 2006-2008, free of clinical CVD and not using lipid-lowering medication. Cross-sectional associations of lipid measures with carotid intima-media thickness (cIMT) and coronary artery calcification (CAC; >0 Agatston score) were examined.
RESULTS: LDL-P was significantly positively associated with cIMT and maintained this association after adjustments for LDL-C and other lipid measures. Although these lipid measures were positively associated with cIMT, model adjustment for LDL-P removed any significant relationships. Higher LDL-P was associated with a significantly higher odds ratio of CAC and further adjustment for LDL-C did not affect this relationship. In contrast, the LDL-C association with CAC was no longer significant after adjustment for LDL-P. Other lipid measures attenuated associations of LDL-P with CAC. Likewise, associations of these measures with CAC were attenuated when model adjustments for LDL-P were made.
CONCLUSIONS: In a community-based sample of Japanese men, free of clinical CVD, LDL-P was a robust marker for subclinical atherosclerosis, independent of LDL-C and other lipid measures. Associations of LDL-C and other lipid measures with either cIMT or CAC were generally not independent of LDL-P.

• 出版日期2016-10