Minireview: Applications of Next-Generation Sequencing on Studies of Nuclear Receptor Regulation and Function

作者：Meyer Clifford A; Tang Qianzi; Liu X Shirley^*

来源：Molecular Endocrinology, 2012, 26(10): 1651-1659.

DOI：10.1210/me.2012-1150

Next-generation sequencing technologies have expanded the experimental possibilities for studying the genome-wide regulation of transcription by nuclear receptors, their collaborating transcription factors, and coregulators. These technologies allow investigators to obtain abundance and DNA sequence information in a single experiment. In this review, we highlight proven and potential uses of next-generation sequencing in the study of gene regulation by nuclear receptors. We also provide suggestions on how to effectively leverage this technology in a collaborative environment. (Molecular Endocrinology 26: 1651-1659, 2012)

• 出版日期2012-10
• 单位同济大学