Stenotrophomonas maltophilia in the respiratory tract of medical intensive care unit patients

作者：Saugel B^*; Eschermann K; Hoffmann R; Hapfelmeier A; Schultheiss C; Phillip V; Eyer F; Laugwitz K L; Schmid R M; Huber W

来源：European Journal of Clinical Microbiology & Infectious Diseases, 2012, 31(7): 1419-1428.

DOI：10.1007/s10096-011-1459-8

The purpose of this study was to investigate characteristics of critically ill patients with Stenotrophomonas maltophilia (S. maltophilia) isolated from the respiratory tract, to identify risk factors for S. maltophilia-pneumonia and intensive care unit (ICU) mortality and to analyze antibiotic susceptibility of S. maltophilia. This was a retrospective analysis of 64 medical ICU patients with S. maltophilia in the respiratory tract. Thirty-six patients fulfilled the criteria for diagnosis of pneumonia. A significantly higher lung injury score (LIS) was observed in patients with pneumonia compared to patients with colonization (p = 0.010). Independent risk factors for S. maltophilia-pneumonia were higher Sequential Organ Failure Assessment (SOFA) score (p = 0.009) and immunosuppression (p = 0.014). Patients with S. maltophilia-pneumonia had higher ICU mortality within a 28-day follow-up (p = 0.040) and higher hospital mortality (p = 0.018) than patients with colonization. The highest antibiotic susceptibility rates were observed to trimethoprim-sulfamethoxazole, tigecycline, and moxifloxacin. Higher SOFA score when S. maltophilia was isolated (p = 0.001) and development of renal failure (p = 0.021) were independent risk factors for ICU mortality. Higher SOFA score and immunosuppression are independent risk factors for S. maltophilia-pneumonia. Patients with S. maltophilia-pneumonia have a significantly higher ICU mortality within a 28-day follow-up, hospital mortality and LIS compared to patients with S. maltophilia-colonization.

• 出版日期2012-7
• 单位河北医科大学