Markers of Inflammation in Alveolar Cells Exposed to Fine Particulate Matter From Prescribed Fires and Urban Air

作者：Myatt Theodore A; Vincent Michael S; Kobzik Lester; Naeher Luke P; MacIntosh David L; Suh Helen^*

来源：Journal of Occupational and Environmental Medicine, 2011, 53(10): 1110-1114.

DOI：10.1097/JOM.0b013e3182337605

Objective: To assess the effect of fine particulate matter (PM(2.5)) from different particle sources on tumor necrosis factor- (TNF-) alpha, we measured TNF production from rat alveolar macrophages (AM) and human dendritic cells (DC) exposed to PM(2.5) from different sources. Methods: Fire-related PM(2.5) samples, rural ambient, and urban indoor and outdoor samples were collected in the Southeast United States. Tumor necrosis factor release was measured from rat AM and human DC following incubation with PM(2.5). Results: Tumor necrosis factor release in AMs was greatest for fire-related PM(2.5) compared with other samples (TNF: P value = 0.005; mortality: P value = 0.005). Tumor necrosis factor releases from the DCs and AMs exposed to fire-associated PM(2.5) were strongly correlated (r = 0.87, P value < 0.0001). Conclusions: Particulate matter exposure produces TNF release consistent with pulmonary inflammation in rat AMs and human DCs, with the response in rat AMs differing by particle source.

• 出版日期2011-10