SOS Regulation of qnrB Expression

作者:Wang Minghua; Jacoby George A*; Mills Debra M; Hooper David C
来源:Antimicrobial Agents and Chemotherapy, 2009, 53(2): 821-823.
DOI:10.1128/AAC.00132-08

摘要

In the sequence upstream from qnrB (but not qnrA or qnrS) is a LexA binding site. qnrB was shown to be under SOS control by demonstrating that quinolone susceptibility decreased with increasing temperature in a strain with a recA441(Ts) allele, whereas qnrB expression increased in response to ciprofloxacin or mitomycin C in strains with an intact lexA gene.