A pH-sensitive nanocarrier for co-delivery of doxorubicin and camptothecin to enhance chemotherapeutic efficacy and overcome multidrug resistance in vitro

作者：Li, Zhen; Li, Hongmei; Liu, Lixiang; You, Xinyi; Zhang, Chaofeng^*; Wang, Yue

来源：RSC Advances, 2015, 5(94): 77097-77105.

DOI：10.1039/c5ra15728e

• MESOPOROUS SILICA NANOPARTICLES
• DRUG-DELIVERY
• CONTROLLED-RELEASE
• BREAST-CANCER
• ZINC-OXIDE
• OXIDATIVE STRESS
• QUANTUM DOTS
• PLATFORM
• NANOCAPSULES
• DISSOLUTION

To deliver chemotherapeutic drugs simultaneously, using drug carriers is a feasible strategy for a better synergetic effect. We have constructed hollow silica nanoparticles (HSNPs) sealed with ZnO quantum dots (QDs) as a pH-sensitive nanocarrier, where the HSNPs have large hollow interiors for delivering hydrophobic camptothecin (CPT) and a mesoporous structure for delivering hydrophilic doxorubicin (DOX center dot HCl). This cooperative drug loading has largely increased the drug encapsulation efficiency of both CPT and DOX up to 89.28% and 44.98%, respectively. Meanwhile, the ZnO QD lids in this drug delivery system are found to be rapidly dissolved in the acidic intracellular compartments to trigger pH-sensitive drug release. The co-delivery of multi-drugs with different anticancer mechanisms in the same nanocarrier enables the intracellular release of the drug combinations to greatly enhance chemotherapeutic efficacy and overcome multidrug resistance (MDR).

• 出版日期2015
• 单位中国药科大学