科研之友
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摘要
Objective: To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles. Methods: With a 2-year prospective study of a community sample (N=521) of older people (aged 65+), information on baseline number of health complaints, diagnosis of moderate/severe depressive syndrome (Geriatric Mental State), and genotypes for 5-HTTLPR and MTHFR C677T polymorphisms were ascertained. Interactions between somatic morbidity and the two genotypes were investigated for incident depression. Results: Incident depression was present in 63 (12%) and was associated with worse somatic health. Significant interactions between number of somatic complaints and both genotypes were observed. For the 5-HTTLPR genotypes, the association between the number of somatic disorders and depression was significant in s/s homozygotes (chi(2)=8.80(1 df), p=.003) but not in heterozygotes (chi(2)=0.23, p=.634) or l/l homozygotes (chi(2)=0.04, p=.840). For the MTHFR genotypes, the association between the number of somatic disorders and depression was significant in T/T homozygotes (chi(2)=4.97, p=.026) but not in C/T heterozygotes (chi(2)=1.24, p=.265) or C/C homozygotes (chi(2)=1.04, p=.307). Conclusions: These findings suggest that associations between general somatic morbidity and late-life depression are modified by at least two genes, and that elders with particular genotypes are at greater risk for onset of depression in the presence of somatic ill health.
- 出版日期2009-4
