Development and set-up of a portable device to monitor airway exhalation and deposition of particulate matter

作者：Goldoni Matteo; Caglieri Andrea; De Palma Giuseppe; Longo Sonia; Acampa Olga; Poli Diana; Manini Paola; Apostoli Pietro; Franchini Innocente; Corradi Massimo; Mutti Antonio^*

来源：Biomarkers, 2009, 14(5): 326-339.

DOI：10.1080/13547500902957192

• Particulate matter
• airway deposition
• particle exhalation
• susceptibility
• vital capacity

The aim of this study was to assess and monitor airway exhalation and deposition of particulate matter ( PM). After standardizing inspiratory/ expiratory flow and volumes, a novel device was tested on a group of 20 volunteers and in a field study on workers exposed to cristobalite. Both male and female subjects showed a higher percentage of deposition in the 0.5 mu m channel than in the 0.3 mu m channel on a laser particle counter, but it was higher in the males because of their higher exhaled lung volumes. The device was tested on a wider range of particles (0.3-0.5-1.0-2.5 mu m) in the cristobalite productive division. The device has low intrasubject variability and good reproducibility, with geometric mean of % CV < 5%. Such a measure can be used to assess individual susceptibility to PM, making repeated measures in different environments, and examining the persistence of particles in the airways after a period in polluted environments.

• 出版日期2009
• 单位国家安全生产监督管理总局信息研究院