Antitumor Activities of Kushen: Literature Review

作者：Sun Mingyu^*; Cao Hongyan; Sun Lin; Dong Shu; Bian Yanqin; Han Jun; Zhang Lijun; Ren Shuang; Hu Yiyang; Liu Chenghai; Xu Lieming; Liu Ping

来源：Evidence-Based Complementary and Alternative Medicine, 2012, 373219.

DOI：10.1155/2012/373219

To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents.

• 出版日期2012
• 单位中国人民解放军第二军医大学; 辽宁中医药大学; 上海中医药大学